Food Toxicology Conference 2021

 

U.S. Food and Drug Administration

Nanotechnology at the U.S. Food and Drug Administration

 

The U.S. FDA has made significant progress in learning about nanomaterial and nanotechnology through internal research, collaborations and engagement with stakeholders. Since the release of the Nanotechnology Task Force report in 2007, FDA has established infrastructure facilities, provided guidance documents to support industry, reviewed and approved many products that utilize nanotechnology.  FDA helped facilitate consensus standards development and collaborated with domestic and international regulatory agencies and stakeholders to address knowledge and policy gaps. A summary of these activities is published in a report by the FDA in July 2020 and will be presented.

 

Dr Anil Patri serves as the Chair, Nanotechnology Task Force and Director of Nanocore, National Center for Toxicological Research, US Food and Drug Administration. His laboratory is very active in regulatory science research to understand material characteristics, safety and efficacy of products containing nanomaterial, and provides training to scientists and reviewers at FDA.  He serves on the U.S. National Nanotechnology Initiative (NNI) NSET Subcommittee and NEHI working group for inter-agency coordination. He is as member of ISO TC229 and serves on the executive committee of ASTM E56 to facilitate standards development in Nanotechnology. He co-chairs the EU-US Nanomedicine and Characterization Communities of Research.

Prior to joining FDA in 2014, Dr Patri served as the Deputy Director, Nanotechnology Characterization Laboratory at the National Cancer Institute. In a decade-long tenure at NCL, he assisted collaborators from industry and academia towards clinical translation of drug products utilizing nanotechnology. From 2006-2014, he also served as a guest scientist at the National Institute of Standards and Technology (NIST). Dr Patri developed nanotechnology-based targeted drug delivery and imaging agents for cancer until 2004 at the Center for Biologic Nanotechnology, University of Michigan Medical School. He obtained his Ph.D. from University of South Florida, conducting basic research on dendritic nanomaterial.

 

National Center for Nanoscience and Technology of China

Application of Nanotechnologies on Food Development and Agriculture in China

 

With the rapid development of nanotechnology, the presence of nanoparticles (NPs) in commercially available products is becoming more and more common. Food security, packaging materials, disease treatment, delivery systems, bioavailability, new tools for molecular and cellular biology and new materials for pathogen detection are examples of the important items that are linked with nanotechnology within the food production chain. In this talk, we will focus on the following topics arising around related to nanotechnology in food industry: 1) Entry trough the gastrointestinal tract and target tissues and other different routes for uptake of engineered nanoparticles; 2) Concepts and progress of present nanotoxicology, including the need for targeted in vitro and in vivo studies. We summarize our recent progress of probing the nano-bio interaction of nanomaterials, focus on the driving force and redox reaction at nano-bio interface.

 

Chunying Chen is currently is a principal investigator at Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety in National Center for Nanoscience and Technology of China. She is one of the earliest researchers in this new field in China. Her research interests include the interaction of nanoparticles with biological systems including protein corona, safe-by design for theranostic nanomedicine systems and vaccine treatments using nanomaterials as potential non-viral vectors.

 

Professor Chen has authored/co-authored over 280 peer-reviewed papers, including Nature Nanotechnology, Nature Methods, Nature Communication, PNAS, JACS, Advanced Materials, Nano Letters, ACS Nano, Chemical Society Reviews, and Accounts of Chemical Research. She is currently an Associated Editor or EB of Science Bulletin, NanoImpact, Nanoscale, Nanoscale Advances, Particle and Fiber Toxicology, Nanotoxicology, Metallomics, Toxicology Research, etc. She has been awarded the Second Prize of the National Natural Science Award in 2018 and 2012 and China Outstanding Young Female Scientists in 2014. 

 

Executive Director, National Nanotechnology Center (NANOTEC), Thailand

Opportunities for Nanotechnology in Food and Food Packaging

 

Nanotechnology has demonstrated significant contributions in food and food packaging. This presentation will highlight some key aspects of nanotechnology, nanomaterials, research and testing capabilities having impact on food and packaging development. Nanoemulsion is emphasized in the fabricated encapsulating systems of food functional compounds to prevent their degradation and improve their bioavailability. Several functional specialty oils (i.e. camellia oil, perilla oil, and oregano oil) are formulated into self-emulsifying oil formulations (SEOF) to enhance the aqueous dispersibility and intestinal retention to achieve higher bioavailability. With regard to food packaging, a brief on development and potential use of lignin nanoparticles (LNPs), based on its combined advantages of natural biopolymer and nanotechnology attributes, will be covered. In the scope of safe and effective utilization of nanomaterials, the toxicological data from reliable predictive models are crucial. We, thus, focus on development of predictive models of in vitro 3D-tissue (such as 3D-intestinal model derived from human intestinal organoids) and an in vivo zebrafish model.

 

Dr Chinsirikul received her B.Sc. (Honors) in Polymer & Textile from Chulalongkorn University (Thailand), M.S. in Polymer Science and Ph.D. in Materials Science and Engineering from The Pennsylvania State University (USA). Her primary area of research is polymer blends, characterization (thermal analysis), film processing and plastic packaging. Her research focus is on ‘Structure-Property-Process’ Relationships.

Research work of her team on the ‘Breathable Film for Tropical Fresh Produce’ has been commercialized. Among received national and international S&T awards and honors, in 2005, her team was a recipient of the ‘Outstanding Technologist Award’, for the achievement on “Active Packaging Film for Shelf-life Extension of Fresh Fruits and Vegetables”, by Foundation for the Promotion of Science and Technology under the Patronage of H.M. the King, Thailand. Dr. Chinsirikul is coauthor of a book chapter entitled Current and Innovative Packaging Technologies for Tropical and Subtropical Fruits in Tropical and Subtropical Fruit Processing and Packaging, Siddiq M (editor), John-Wiley Publishing Co., Ames, Iowa, USA, 2012.

At present, she serves as an executive committee member of Asia Nano Forum (ANF), Asian Workshop on Polymer Processing (AWPP), president of Nanotechnology Association of Thailand, and a past board member of International Association of Packaging Research Institutes (IAPRI), 2015-2020.